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Zannatul Ferdous

Zannatul Ferdous

Assistant Professor


2011 - Present Assistant Professor, Department of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, TN

2008 - 2011 Postdoctoral Fellow, Georgia Institute of Technology, Biomedical Engineering


  • Disease Development & Remodeling in Heart Valves
  • Cellular Mechanobiology & Electrophysiology
  • Heart Valve Biomechanics & Tissue Engineering
  • Biomarkers for Early Detection & Treatment in Valves
  • Bioreactor Systems for Native & Engineered Systems


  • Ph.D., B.M.E., 2008, Rice University, Houston, TX
  • B.S., E.E., 2003, Kansas State University, KS

Professional Service

  • American Heart Association
  • Biomedical Engineering Society
  • Center for Biological and Environmental Nanotechnology


Lei, Y.; Masjedi, S.; Ferdous, Z. "A Study of Extracellular Matrix Remodeling in Aortic Heart Valves Using a Novel Biaxial Stretch Bioreactor". Submitted.

Davari, S. A.; Masjedi, S.; Ferdous, Z.; Mukherjee, D. "In-vitro analysis of early calcification in aortic valvular interstitial cells using Laser-Induced Breakdown Spectroscopy (LIBS)". Submitted.

Masjedi, S.; Lei, Y.; Patel, J.; Ferdous, Z. "Sex-related Differences in Matrix Remodeling and Early Osteogenic Markers in Aortic Valvular Interstitial Cells". Heart and Vessels, in press.

Masjedi, S.; Amarnath, A.; Bailey, K. M.; Ferdous, Z. “Comparison of Calcification Potential of Valvular Interstitial Cells Isolated from Individual Aortic Valve Cusps”. Cardiovascular Pathology (2016), 25(3):185–94.

Rathan, S., Holliday-Ankeny, C.J., Arjunon, S., Ferdous, Z., Kumar, S., Esmerats, J.F., Heath, J.M., Nerem, R.M., Yoganathan, A., and Jo, H. "Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis". Nature Scientific Reports (2016), 6:25397. DOI: 10.1038/srep25397.

Lei, Y.; Ferdous, Z. "Design Considerations and Challenges for Mechanical Stretch Bioreactors in Tissue Engineering". Biotechnology Progress (2016), 32(3):543-53.

Masjedi, S.; Ferdous, Z. “Understanding the Role of Sex in Heart Valve and Major Vascular Diseases”. Cardiovascular Engineering and Technology (2015), 6(3):209-219.

Ferdous, Z.*; Jo, H.; Nerem, R.M. “Strain Magnitude-dependent Calcific Marker Expression in Valvular and Vascular Cells”. Cells Tissues Organs (2013), Vol. 197(5), Pg. 372-83. * corresponding author.

Ferdous, Z.*; Jo, H.; Nerem, R.M. “Differences in Valvular and Vascular Cell Responses to Strain in Osteogenic Media”. Biomaterials (2011), Vol. 32, Pg. 2885-2893. * corresponding author.

Ferdous, Z.*; Peterson, S.B.*; Tseng, H.*; Anderson, D.K., Iozzo, R.V., Grande-Allen, K.J. “A Role For Decorin in Controlling Proliferation, Adhesion, and Migration of Murine Embryonic Fibroblasts”. Journal of Biomedical Materials Research part A (2010), Vol. 93(2), Pg. 419-28. * equal contribution.

Ferdous, Z.; Lazaro, L.D.; Iozzo, R.V.; Höök, M.; Grande-Allen, K.J. “Influence of Cyclic Strain and Decorin Deficiency on 3D Cellularized Collagen Matrices”. Biomaterials (2008), Vol. 29(18), Pg. 2740-8.

Ferdous, Z.; Wei, V.M.; Iozzo, R.V.; Höök, M.; Grande-Allen, K.J. “Decorin-TGF-beta Interaction Regulates Matrix Organization and Mechanical Characteristics Of 3-D Collagen Matrices”. Journal of Biological Chemistry (2007), Vol. 282(49), Pg. 35887-98.

Ferdous, Z.; Grande-Allen, K.J. “Utility and Control of Proteoglycans in Tissue Engineering”. Tissue Engineering (2007), Vol. 13(8), Pg. 1893-1904.

Pandey, S.; Ferdous, Z.; White, M. H. “A Planar MEMS Bio- Chip for Recording Ion Channel Currents in Biological Cells”.  Proceedings of the SPIE (2003), Vol. 5062, Pg. 814-20.

Zannatul Ferdous

Contact Information

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