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Xiaopeng Zhao

Xiaopeng Zhao

Associate Professor


Associate Professor, Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville

Senior Personnel, National Institute for Mathematical and Biological Synthesis, Knoxville

Assistant Professor, Department of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville

Research Associate, Department of Biomedical Engineering, Duke University

Research Associate, Department of Engineering Science and Mechanics, Virginia Tech


  • Medical Informatics
  • Computational Biology
  • Disease Modeling
  • Cardiovascular Dynamics
  • Dynamics and Control


Ph.D. 2004, Virginia Tech

M.S. 1999, Tsinghua University, China

B.S. 1996, Tsinghua University, China

Professional Service

  • IEEE Engineering in Medicine and Biology Society (EMBS)
  • American Society of Mechanical Engineers (ASME) - Dynamic Systems & Control Division (DSCD)
  • Biomedical Engineering Society
  • Society for Industrial and Applied Mathematics (SIAM)

Awards and Recognitions

  • Quest Scholar of the Week, January 2010
  • Computing in Cardiology Challenge Award, 2010 and 2011
  • 2009 NSF CAREER Award
  • Physionet Challenge 2010, Second Place
  • Physionet Challenge 2011, First Place


Xiaopeng Zhao, Henian Xia, Irfan Asif, Dale C Wortham, and Elena G Tolkacheva, Resampling for Reliable Evaluation and Improved Performance Inautomatic Detection Ofelectrode Misplacements In Ecg: Studies Based On Limb-Lead Misplacements, Journal of Biomedical Technology and Research, 1(1):9, 2014.

Cecile Gotteland, Brent M McFerrin, Xiaopeng Zhao, Emmanuelle Gilot-Fromont and Maud Lelu, Agricultural landscape and spatial distribution of Toxoplasma gondii in rural environment: an agent-based model, International Journal of Health Geographics, 13:45, 2014.

Andrew Kail, Kwai Wong, Henian Xia, Xiaopeng Zhao, Interoperable executive library for the simulation of biomedical processes, Journal of Computational and Applied Mathematics, 270, 257-274, 2014.

J. McBride†, X. Zhao, N. Munro, C. Smith, G. Jicha, L. Hively, L. Broster, F.A. Schmitt, R.J. Kryscio, and Y. Jiang, Spectral and Complexity Analysis of Scalp EEG Characteristics for Mild Cognitive Impairment and Early Alzheimer’s Disease, Computer Methods and Programs in Biomedicine, 114 (153-163), 2014.

H. Xia, G. Garcia, J. Bains, D. Wortham, and X. Zhao, Matrix of Regularity for Improving the Quality of ECG, in Focus issues: Signal quality in cardiorespiratory monitoring,  Physiological Measurement, 33:1535-1548, 2012

H. Xia, G. Garcia, and X. Zhao, Automatic Detection of Electrode Misplacement in ECG: A Tale of Two Algorithms, in Focus issues: Signal quality in cardiorespiratory monitoring, Physiological Measurement, 33:1549-1561, 2012

A. Sullivan, F. Agusto, S. Bewick, C. Su, S. Lenhart, and X. Zhao, A Mathematical Model for Within-host Toxoplasma gondii Invasion Dynamics, Mathematical Biosciences and Engineering, 9:647-662, 2012

Y. Wu, M. Zhang, J. Wu, X. Zhao, L. Xia, Evolutionary Game Theoretic Strategy for Optimal Drug Delivery to Influence Selection Pressure in Treatment of HIV-1, Journal of Mathematical Biology, 64: 495-512, 2012

W. Jiang, A. Sullivan, C. Su, and X. Zhao, An Agent-based Model for the Transmission Dynamics of Toxoplasma Gondii, Journal of Theoretical Biology, 293, 15–26, 2012.

E.G. Tolkacheva and X. Zhao, “Nonlinear dynamics of periodically paced cardiac tissue”, Nonlinear Dynamics, 68:347-376, 2012.

W. Jiang and X. Zhao, “Dynamics and Control of the Two-pulse Protocol in Electroporation: Numerical Exploration,” Mathematical Biosciences, 232: 24-30, 2011.

J. McBride, A. Sullivan, H. Xia, A. Petrie, and X. Zhao, “Reconstruction of physiological signals using iterative retraining and accumulated averaging of neural network models,” Physiological Measurement, 32: 661-675, 2011.

L. Xia, S.C. Lenaghan, M. Zhang, Y. Wu, X. Zhao, J.N. Burris and C.N. Stewart Jr., “Characterization of English ivy (Hedera helix) adhesion force and imaging using atomic force microscopy,” Journal of Nanoparticle Research, 13:1029–1037, 2011.

Y. Wu, L. Xia, M. Zhang, and X. Zhao, “Immunodominance analysis through interactions of CD8+ T cells and DCs in lymph nodes,” Mathematical Biosciences, 225, 53-58, 2010.

Y. Wu, X. Zhao, and M. Zhang, “Adhesion Mechanics of Ivy Nanoparticles,” Journal of Colloid and Interface Science, 344:533-540, 2010.

X. Zhao, R. Yang, M. Zhang, and H. Xia, “A Computational Approach for Understanding Immunodominance Based on Optimal Control Formulation,” Communications in Nonlinear Science and Numerical Simulations, 15, 4209–4218, 2010.

X. Zhao, M. Zhang, and R. Yang “Control of Pore Radius Regulation for Electroporation-based Drug Delivery,” Communications in Nonlinear Science and Numerical Simulations, 15:1400-1407, 2010.

X. Zhao, “Indeterminacy of Spatiotemporal Cardiac Alternans,” Physical Review E, 78, 011902, 2008. Selected to appear in the July 15, 2008 issue of Virtual Journal of Biological Physics Research.

X. Zhao, D.G. Schaeffer, C.M. Berger, D.J. Gauthier, and W. Krassowska, “Cardiac Alternans Arising from an Unfolded Border-collision bifurcation”, Journal of Computational and Nonlinear Dynamics, 4, 041004, 2008.

D.G. Schaeffer, W. Ying, and X. Zhao, “Asymptotic Approximation of an Ionic Model for Cardiac Restitution”, Nonlinear Dynamics, Vol. 51, pp. 189-198, 2008

X. Zhao, D.G. Schaeffer, “Alternate Pacing of Border-collision Period-doubling Bifurcations”, Nonlinear Dynamics, Vol. 50, pp. 733-742, 2007.

C.M. Berger, X. Zhao, D.G. Schaeffer, W. Krassowska, H.M. Dobrovolny, and D.J. Gauthier, “Period-doubling bifurcation to alternans in paced cardiac tissue: Crossover from smooth to border-collision characteristics”, Physical Review Letters, Vol. 99, 058101, 2007. Selected to appear in the Virtual Journal of Biological Physics Research, Volume 14, Issue 3, August 1, 2007.

H. Dankowicz, X. Zhao, S. Misra, “Near-Grazing Dynamics in Tapping-Mode Atomic Force Microscopy”, International Journal of Non-linear Mechanics, Vol. 42, pp. 697-709, 2007.

X. Zhao, D.G. Schaeffer, C.M. Berger, and D.J. Gauthier, “Small Signal Amplification of Period-doubling Bifurcations in Smooth Iterated Maps”, Nonlinear Dynamics, Vol. 48, pp. 381-389, 2007.

X. Zhao and H. Dankowicz, “Unfolding Degenerate Grazing Dynamics in Impact Actuators”, Nonlinearity, Vol. 19, pp. 399-418, 2006.

X. Zhao and H. Dankowicz, “Characterization of Intermittent Contacts in Tapping Mode Atomic Force Microscopy”, ASME Journal of Computational and Nonlinear Dynamics, Vol. 2, 2006.

P. Thota, X. Zhao, and H. Dankowicz, “Co-dimension-two grazing bifurcations in single-degree-of-freedom impact oscillators”, ASME Journal of Computational and Nonlinear Dynamics, Vol. 1, pp. 328-335, 2006.

X. Zhao and H. Dankowicz, “Control of Impact Microactuators for Precise Positioning”, ASME Journal of Computational and Nonlinear Dynamics, Vol. 1, pp. 65-70, 2006.

H. Dankowicz and X. Zhao, "Local Analysis of Co-dimension-one and Co-dimension-two grazing bifurcations in Impact Microatuators", Physica D, Vol. 202, pp. 238-257, 2005.

X. Zhao, C.K. Reddy, and A.H. Nayfeh, "Nonlinear Dynamics of an Electrically Driven Impact Microactuator", Nonlinear Dynamics, Vol. 40, pp. 227-239, 2005.

X. Zhao, H. Dankowicz, C.K. Reddy, and A.H. Nayfeh, "Modeling and Simulation Methodology for Impact Microactuators", Journal of Micromechanics and Microengineering, Vol. 14, pp. 775-784, 2004.

X. Zhao, E.M. Abdel-Rahman, and A.H. Nayfeh, "A Reduced-Order Model for Electrically Actuated Microplates", Journal of Micromechanics and Microengineering, Vol. 14, pp. 900-906, 2004.

Xiaopeng Zhao

Contact Information

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